Profhilo vs Polynucleotides at The Medispa: Which Skin Booster Is Right for You?

If you’re seeking radiant, youthful, and naturally rejuvenated skin, two leading treatments dominate the aesthetics landscape Profhilo and Polynucleotides.

At The Medispa, with doctor-led clinics in Telford, Shrewsbury, Wolverhampton, and Walsall, we’ve seen a surge in demand for these advanced injectables. Both work to revitalize skin from within but their mechanisms are scientifically distinct.

Here, our experts explain the science behind each treatment, how they differ, and how we help you choose the perfect option for your skin.

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Profhilo: The Science of Bio-Remodelling

Often described as “injectable skincare,” Profhilo is a breakthrough in bioremodelling technology, designed to hydrate, tighten, and rejuvenate the skin — without altering facial structure.

Unlike traditional dermal fillers, which add volume, Profhilo works by stimulating your body’s natural regenerative processes.

How Profhilo Works

Profhilo contains one of the highest concentrations of pure hyaluronic acid (HA) available—64 mg in a single 2 ml syringe—but what sets it apart is the patented NAHYCO® Hybrid Technology. This process thermally bonds high molecular weight (H-HA) and low molecular weight (L-HA) hyaluronic acid molecules into stable hybrid complexes.

• High molecular weight HA provides deep, long-lasting hydration and structural support.
  

• Low molecular weight HA penetrates deeper layers, triggering fibroblast stimulation to increase collagen and elastin synthesis.
  
  

This dual action creates a bio-remodelling effect, improving skin elasticity, firmness, and smoothness from within.

At The Medispa, Profhilo is ideal for:

• Dull, dehydrated, or tired-looking skin
  

• Fine lines, crepiness, or mild sagging on the face, neck, or décolletage
  

• Clients wanting a fresh, luminous glow without added volume
  
  

After two sessions (four weeks apart), clients notice visibly tighter, more hydrated skin with improved elasticity — results that continue to evolve over the following months as new collagen forms.

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Polynucleotides: Advanced Cellular Regeneration

While Profhilo focuses on hydration and firmness, Polynucleotides go a step deeper — into true cellular regeneration.

Derived from purified, filtered DNA fragments (usually salmon or trout DNA, chosen for its exceptional biocompatibility), Polynucleotides are biostimulators that repair damaged tissue, improve cell turnover, and restore the skin’s microenvironment.

How Polynucleotides Work

Polynucleotides act through several biological mechanisms:

1. Cellular Regeneration:
   They stimulate fibroblast proliferation, the cells responsible for collagen and elastin production, leading to improved skin structure and density.
   

2. DNA Repair and Antioxidant Action:
   Polynucleotides scavenge free radicals, reducing oxidative stress — one of the main causes of premature ageing.
   

3. Tissue Healing and Hydration:
   They attract water molecules and improve the extracellular matrix, enhancing skin elasticity and hydration while repairing microdamage.
   

4. Anti-Inflammatory Effect:
   Polynucleotides modulate inflammatory processes, making them ideal for sensitive, rosacea-prone, or post-procedure skin.
   
   

At The Medispa, Polynucleotides are often chosen for:

• Sensitive, inflamed, or compromised skin
  

• Redness, thinning, or loss of elasticity
  

• Mature or photo-damaged skin needing regeneration
  
  

Results build progressively as the skin’s natural repair systems activate — improving tone, resilience, and overall skin health.

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Profhilo vs Polynucleotides: A Scientific Comparison

Both treatments complement each other beautifully. In many cases, our medical team designs combination protocols using both Profhilo and Polynucleotides to achieve multi-layered rejuvenation — hydration, repair, and regeneration.

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The Medispa’s Doctor-Led Approach

Choosing between Profhilo and Polynucleotides depends on your skin condition, goals, and lifestyle.

• Choose Profhilo if you want to target dehydration, dullness, or early signs of ageing.
  

• Choose Polynucleotides if you’re focused on repairing damaged, red, or inflamed skin.
  

• Combine both for comprehensive rejuvenation — many of our clients begin with Profhilo to hydrate and follow with Polynucleotides for long-term repair.
  
  

At The Medispa, every treatment is designed by our doctor-led aesthetics team, ensuring the safest, most ethical, and effective plan tailored to your skin.

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Enhance Your Results with The Medispa Skincare Range

To maintain results between treatments, we recommend pairing your injectable skin boosters with medical-grade skincare available exclusively at The Medispa:

• HA Intensifier Multi-Glycan – enhances hyaluronic acid production, ideal post-Profhilo.
  

• Age Interrupter Advanced – supports collagen structure and combats visible ageing, synergising with Polynucleotide therapy.
  

• Cell Cycle Catalyst – accelerates skin renewal and radiance post-procedure.
  
  

These advanced formulations protect and prolong your results, ensuring your skin remains hydrated, firm, and glowing.

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Real Results Across Telford, Shrewsbury, Wolverhampton & Walsall

Patients describe their Profhilo and Polynucleotide results as transformative yet natural. The glow is noticeable, the texture improved, but the outcome remains subtle — true to The Medispa philosophy of natural, ethical aesthetics.

Each of our clinics provides a calm, elegant, doctor-led environment where you can relax knowing your skin is in expert medical hands.

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Frequently Asked Questions

How long do results last?
Profhilo results typically last 6–9 months. Polynucleotide results can last up to 12 months depending on skin health and maintenance.

Can I combine Profhilo and Polynucleotides?
 Yes, many clients benefit from combining both treatments for enhanced hydration, repair, and regeneration.

Is there downtime?
Minimal. Small bumps at the injection sites may appear for 24–48 hours and settle quickly.

When will I see results?
Profhilo results appear within 1–2 weeks. Polynucleotides build gradually over 3–6 weeks as the skin regenerates.

Are these treatments suitable for men and women?
 Absolutely. Both are safe and effective for all skin types and tones.

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Book Your Skin Booster Consultation at The Medispa

At The Medispa, every treatment combines medical precision, advanced science, and aesthetic artistry. Whether you choose Profhilo, Polynucleotides, or a bespoke combination protocol, our mission is to help your skin look healthier, firmer, and beautifully natural.

Book your doctor-led consultation today at one of our clinics in Telford, Shrewsbury, Wolverhampton, or Walsall, and discover The Medispa difference.

👉 Book Now